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Moreover, an increased intracellular ROS-availability can shift the reduced GSH toward a more oxidized GSH (i.e., GSSG) status (Anjum et al., 2012)

Glutathione, however, is not a direct product of the methionine cycle, as it depends on the function of additional enzymes and the availability of additional components outside those of the methionine cycle

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Tissue Barriers 2:e944446

For example, thiamine is critical for converting carbohydrates into ATP, while pyridoxine supports immune function and mood regulation